Elmyra Duff (voiced by Cree Summer) is an orange-headed girl. She wears a blue blouse, a white skirt, black Mary Jane shoes over white socks and a blue bow with a skull at the center. Based on Elmer Fudd, she is a total role reversal of Elmer: instead of hunting animals, she cares for them to selfish lengths and falls into the stereotype of the spoiled and piercing-voiced girl. She is one of the few human characters in the series, and like the animal characters, she attends Acme Looniversity where she also serves as the nurse to the point of sometimes duplicating herself like in The Acme Bowl where two Elmyras are skipping happily carrying injured players off the football field in the game against Perfecto Prep. In one episode, Elmyra's family is shown, including her mother, inventor father, typical 90's teen sister, a brother about the same age as her, a super strong baby brother, and a maid.
Elmyra is obsessed with having animals as pets, and will chase them or trap them in order to take them to her house. Despite everything, she is utterly oblivious to the abuse she is inflicting onto animals.
She makes a few appearances in Animaniacs and starred along with Pinky and the Brain in a spinoff, Pinky, Elmyra and the Brain.
In several episodes, it is revealed that she wears a wig. Her baldness provides further connection with Elmer Fudd.